Structures of the holo CRISPR RNA-guided transposon integration complex

CRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism(1–3). CAST elements contain multiple conserved proteins: a CRISPR effector (Cas12k or Cascade), a AAA+ regulator (TnsC), a transposase (TnsA–TnsB) and a target-sit...

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Detalles Bibliográficos
Autores principales: Park, Jung-Un, Tsai, Amy Wei-Lun, Rizo, Alexandrea N., Truong, Vinh H., Wellner, Tristan X., Schargel, Richard D., Kellogg, Elizabeth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876797/
https://www.ncbi.nlm.nih.gov/pubmed/36442503
http://dx.doi.org/10.1038/s41586-022-05573-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876797/
https://www.ncbi.nlm.nih.gov/pubmed/36442503
http://dx.doi.org/10.1038/s41586-022-05573-5

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