An mTOR feedback loop mediates the ‘flare’ (‘rebound’) response to MET tyrosine kinase inhibition

Targeted therapy significantly impairs tumour growth but suffers from limitations, among which the ‘flare’ (‘rebound’) effect. Among cancers driven by tyrosine kinase receptors, those relying on alterations of the MET oncogene benefit from treatment by specific inhibitors. Previously, we reported th...

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Detalles Bibliográficos
Autores principales: Altintas, D. M., Cerqua, M., De Laurentiis, A., Trusolino, L., Boccaccio, C., Comoglio, P. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876934/
https://www.ncbi.nlm.nih.gov/pubmed/36697438
http://dx.doi.org/10.1038/s41598-023-28648-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876934/
https://www.ncbi.nlm.nih.gov/pubmed/36697438
http://dx.doi.org/10.1038/s41598-023-28648-3

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