Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach

Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathematical modelling. Previously, a non-linear mixed-ef...

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Detalles Bibliográficos
Autores principales: Michelet, Robin, Bindellini, Davide, Melin, Johanna, Neumann, Uta, Blankenstein, Oliver, Huisinga, Wilhelm, Johnson, Trevor N., Whitaker, Martin J., Ross, Richard, Kloft, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877293/
https://www.ncbi.nlm.nih.gov/pubmed/36712688
http://dx.doi.org/10.3389/fphar.2022.1090554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877293/
https://www.ncbi.nlm.nih.gov/pubmed/36712688
http://dx.doi.org/10.3389/fphar.2022.1090554

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