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Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach
Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathematical modelling. Previously, a non-linear mixed-ef...
Autores principales: | Michelet, Robin, Bindellini, Davide, Melin, Johanna, Neumann, Uta, Blankenstein, Oliver, Huisinga, Wilhelm, Johnson, Trevor N., Whitaker, Martin J., Ross, Richard, Kloft, Charlotte |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877293/ https://www.ncbi.nlm.nih.gov/pubmed/36712688 http://dx.doi.org/10.3389/fphar.2022.1090554 |
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