Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells

Background: The cGAS/STING pathway, part of the innate immune response to foreign DNA, can be activated by cell’s own DNA arising from the processing of the genome, including the degradation of nascent DNA at arrested replication forks, which can be upregulated in cancer cells. Recent evidence raise...

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Detalles Bibliográficos
Autores principales: Lazarchuk, Pavlo, Nguyen, Vy N., Brunon, Salomé, Pavlova, Maria N., Sidorova, Julia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877313/
https://www.ncbi.nlm.nih.gov/pubmed/36710880
http://dx.doi.org/10.3389/fmolb.2022.1048726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877313/
https://www.ncbi.nlm.nih.gov/pubmed/36710880
http://dx.doi.org/10.3389/fmolb.2022.1048726

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