TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance

Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated in urothelial cell-derived carcinomas or urothelial carcinomas (UCs) including UC of the bladder (UCB) and upper track UC (UTUC). Te...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Tiantian, Li, Shihong, Xia, Chuanyou, Xu, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877314/
https://www.ncbi.nlm.nih.gov/pubmed/36713366
http://dx.doi.org/10.3389/fimmu.2022.1071390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877314/
https://www.ncbi.nlm.nih.gov/pubmed/36713366
http://dx.doi.org/10.3389/fimmu.2022.1071390

Ejemplares similares