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TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance

Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated in urothelial cell-derived carcinomas or urothelial carcinomas (UCs) including UC of the bladder (UCB) and upper track UC (UTUC). Te...

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Detalles Bibliográficos
Autores principales:	Liu, Tiantian, Li, Shihong, Xia, Chuanyou, Xu, Dawei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877314/ https://www.ncbi.nlm.nih.gov/pubmed/36713366 http://dx.doi.org/10.3389/fimmu.2022.1071390

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