Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates

Introduction: Most hepatically cleared drugs are metabolized by cytochromes P450 (CYPs), and Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines provide curated clinical references for CYPs to apply individual genome data for optimized drug therapy. However, incorporating novel pha...

Descripción completa

Detalles Bibliográficos
Autores principales: Seo, Myung-Eui, Min, Byung-Joo, Heo, Nayoon, Lee, Kye Hwa, Kim, Ju Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877350/
https://www.ncbi.nlm.nih.gov/pubmed/36713839
http://dx.doi.org/10.3389/fphar.2023.1055991

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877350/
https://www.ncbi.nlm.nih.gov/pubmed/36713839
http://dx.doi.org/10.3389/fphar.2023.1055991

Ejemplares similares