ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production

Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphoma cell migration towards CXCL12. Here, we propose...

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Detalles Bibliográficos
Autores principales: Antonello, Paola, Pizzagalli, Diego U., Foglierini, Mathilde, Melgrati, Serena, Radice, Egle, Thelen, Sylvia, Thelen, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878562/
https://www.ncbi.nlm.nih.gov/pubmed/36713377
http://dx.doi.org/10.3389/fimmu.2022.1067885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878562/
https://www.ncbi.nlm.nih.gov/pubmed/36713377
http://dx.doi.org/10.3389/fimmu.2022.1067885

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