Distinct conformational changes occur within the intrinsically unstructured pro‐domain of pro‐Nerve Growth Factor in the presence of ATP and Mg(2+)

Nerve growth factor (NGF), the prototypical neurotrophic factor, is involved in the maintenance and growth of specific neuronal populations, whereas its precursor, proNGF, is involved in neuronal apoptosis. Binding of NGF or proNGF to TrkA, p75(NTR), and VP10p receptors triggers complex intracellula...

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Detalles Bibliográficos
Autores principales: Paoletti, Francesca, Covaceuszach, Sonia, Cassetta, Alberto, Calabrese, Antonio N., Novak, Urban, Konarev, Petr, Grdadolnik, Jože, Lamba, Doriano, Golič Grdadolnik, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878617/
https://www.ncbi.nlm.nih.gov/pubmed/36605018
http://dx.doi.org/10.1002/pro.4563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878617/
https://www.ncbi.nlm.nih.gov/pubmed/36605018
http://dx.doi.org/10.1002/pro.4563

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