Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist

[Image: see text] The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available key starting material, viz., naloxone, and ends with the oxalate...

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Autores principales: Velugula, Siva Rama Kasibabu, Misra, Nimesh Chandra, Chapala, Suresh, Aaramadaka, Sunil Kumar Reddy, Chavakula, Ramadas, Sanasi, Paul Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878627/
https://www.ncbi.nlm.nih.gov/pubmed/36713715
http://dx.doi.org/10.1021/acsomega.2c07305
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author Velugula, Siva Rama Kasibabu
Misra, Nimesh Chandra
Chapala, Suresh
Aaramadaka, Sunil Kumar Reddy
Chavakula, Ramadas
Sanasi, Paul Douglas
author_facet Velugula, Siva Rama Kasibabu
Misra, Nimesh Chandra
Chapala, Suresh
Aaramadaka, Sunil Kumar Reddy
Chavakula, Ramadas
Sanasi, Paul Douglas
author_sort Velugula, Siva Rama Kasibabu
collection PubMed
description [Image: see text] The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available key starting material, viz., naloxone, and ends with the oxalate salt of naloxegol (a pharmaceutically acceptable salt). This novel route has a very high yield and purity greater than 99.5%, substantially free from impurities (less than 1%).
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spelling pubmed-98786272023-01-27 Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist Velugula, Siva Rama Kasibabu Misra, Nimesh Chandra Chapala, Suresh Aaramadaka, Sunil Kumar Reddy Chavakula, Ramadas Sanasi, Paul Douglas ACS Omega [Image: see text] The present article discloses an improved and robust commercial process of the modern medicine naloxegol oxalate, which is used to treat opioid-induced constipation. The synthesis originates from the easily available key starting material, viz., naloxone, and ends with the oxalate salt of naloxegol (a pharmaceutically acceptable salt). This novel route has a very high yield and purity greater than 99.5%, substantially free from impurities (less than 1%). American Chemical Society 2023-01-10 /pmc/articles/PMC9878627/ /pubmed/36713715 http://dx.doi.org/10.1021/acsomega.2c07305 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Velugula, Siva Rama Kasibabu
Misra, Nimesh Chandra
Chapala, Suresh
Aaramadaka, Sunil Kumar Reddy
Chavakula, Ramadas
Sanasi, Paul Douglas
Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist
title Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist
title_full Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist
title_fullStr Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist
title_full_unstemmed Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist
title_short Improved Process for the Preparation of Naloxegol Oxalate, an Opiod Receptor Antagonist
title_sort improved process for the preparation of naloxegol oxalate, an opiod receptor antagonist
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878627/
https://www.ncbi.nlm.nih.gov/pubmed/36713715
http://dx.doi.org/10.1021/acsomega.2c07305
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