Aerosolizable Plasmid DNA Dry Powders Engineered by Thin-film Freezing

PURPOSE: This study was designed to test the feasibility of using thin-film freezing (TFF) to prepare aerosolizable dry powders of plasmid DNA (pDNA) for pulmonary delivery. METHODS: Dry powders of pDNA formulated with mannitol/leucine (70/30, w/w) with various drug loadings, solid contents, and sol...

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Detalles Bibliográficos
Autores principales: Xu, Haiyue, Moon, Chaeho, Sahakijpijarn, Sawittree, Dao, Huy M., Alzhrani, Riyad F., Wang, Jie-liang, Williams, Robert O., Cui, Zhengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879621/
https://www.ncbi.nlm.nih.gov/pubmed/36703028
http://dx.doi.org/10.1007/s11095-023-03473-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879621/
https://www.ncbi.nlm.nih.gov/pubmed/36703028
http://dx.doi.org/10.1007/s11095-023-03473-5

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