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Mitochondria directly sense osmotic stress to trigger rapid metabolic remodeling via regulation of pyruvate dehydrogenase phosphorylation

A high-salt diet significantly impacts various diseases, ilncluding cancer and immune diseases. Recent studies suggest that the high-salt/hyperosmotic environment in the body may alter the chronic properties of cancer and immune cells in the disease context. However, little is known about the acute...

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Detalles Bibliográficos
Autores principales: Ikizawa, Takeshi, Ikeda, Kazutaka, Arita, Makoto, Kitajima, Shojiro, Soga, Tomoyoshi, Ichijo, Hidenori, Naguro, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879793/
https://www.ncbi.nlm.nih.gov/pubmed/36581206
http://dx.doi.org/10.1016/j.jbc.2022.102837