Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors

LKB1 and KRAS are the third most frequent co-mutations detected in non-small cell lung cancer (NSCLC) and cause aggressive tumor growth. Unfortunately, treatment with RAS-RAF-MEK-ERK pathway inhibitors has minimal therapeutic efficacy in LKB1-mutant KRAS-driven NSCLC. Autophagy, an intracellular nut...

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Detalles Bibliográficos
Autores principales: Bhatt, Vrushank, Lan, Taijin, Wang, Wenping, Kong, Jerry, Lopes, Eduardo Cararo, Wang, Jianming, Khayati, Khoosheh, Raju, Akash, Rangel, Michael, Lopez, Enrique, Hu, Zhixian Sherrie, Luo, Xuefei, Su, Xiaoyang, Malhotra, Jyoti, Hu, Wenwei, Pine, Sharon R., White, Eileen, Guo, Jessie Yanxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879981/
https://www.ncbi.nlm.nih.gov/pubmed/36702816
http://dx.doi.org/10.1038/s41419-023-05592-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879981/
https://www.ncbi.nlm.nih.gov/pubmed/36702816
http://dx.doi.org/10.1038/s41419-023-05592-8

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