SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β–induced synaptic pathology

Amyloid-β oligomers (AβOs), toxic peptide aggregates found in Alzheimer’s disease, cause synapse pathology. AβOs interact with neurexins (NRXs), key synaptic organizers, and this interaction dampens normal trafficking and function of NRXs. Axonal trafficking of NRX is in part regulated by its intera...

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Detalles Bibliográficos
Autores principales: Lee, Alfred Kihoon, Yi, Nayoung, Khaled, Husam, Feller, Benjamin, Takahashi, Hideto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880023/
https://www.ncbi.nlm.nih.gov/pubmed/36697254
http://dx.doi.org/10.26508/lsa.202201681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880023/
https://www.ncbi.nlm.nih.gov/pubmed/36697254
http://dx.doi.org/10.26508/lsa.202201681

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