Identification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening

INTRODUCTION: WNK [with no lysine (K)] kinases are serine/threonine kinases associated with familial hyperkalemic hypertension (FHHt). WNKs are therapeutic targets for blood pressure regulation, stroke and several cancers including triple negative breast cancer and glioblastoma. Here, we searched fo...

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Detalles Bibliográficos
Autores principales: Chlebowicz, Julita, Akella, Radha, Humphreys, John M, He, Haixia, Kannangara, Ashari R, Wei, Shuguang, Posner, Bruce, Goldsmith, Elizabeth J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880028/
https://www.ncbi.nlm.nih.gov/pubmed/36712947
http://dx.doi.org/10.2147/DDDT.S389461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880028/
https://www.ncbi.nlm.nih.gov/pubmed/36712947
http://dx.doi.org/10.2147/DDDT.S389461

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