AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity

The ataxia-linked protein sacsin has three regions of partial homology to Hsp90’s N-terminal ATP binding domain. Although a crystal structure for this Hsp90-like domain has been reported the precise molecular interactions required for ATP-binding and hydrolysis are unclear and it is debatable whethe...

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Detalles Bibliográficos
Autores principales: Perna, Laura, Castelli, Matteo, Frasnetti, Elena, Romano, Lisa E. L., Colombo, Giorgio, Prodromou, Chrisostomos, Chapple, J. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880540/
https://www.ncbi.nlm.nih.gov/pubmed/36710881
http://dx.doi.org/10.3389/fmolb.2022.1074714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880540/
https://www.ncbi.nlm.nih.gov/pubmed/36710881
http://dx.doi.org/10.3389/fmolb.2022.1074714

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