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Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein. Huntingtin is subjected to multiple post-translational modifications which r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880554/ https://www.ncbi.nlm.nih.gov/pubmed/36711022 http://dx.doi.org/10.3389/fphys.2023.1086112 |