Evaluation of rAAVrh74 gene therapy vector seroprevalence by measurement of total binding antibodies in patients with Duchenne muscular dystrophy

BACKGROUND: Adeno-associated virus (AAV) vectors are a promising platform for in vivo transfer of transgenes designed to treat diseases. Pre-existing humoral immunity to these vectors can potentially impact the safety and efficacy of gene therapies. Consequently, individuals with pre-existing antibo...

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Detalles Bibliográficos
Autores principales: Goedeker, Natalie L., Dharia, Sachi D., Griffin, Danielle A., Coy, Jesantha, Truesdale, Todd, Parikh, Rajan, Whitehouse, Kasen, Santra, Sourav, Asher, Damon R., Zaidman, Craig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880577/
https://www.ncbi.nlm.nih.gov/pubmed/36710722
http://dx.doi.org/10.1177/17562864221149781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880577/
https://www.ncbi.nlm.nih.gov/pubmed/36710722
http://dx.doi.org/10.1177/17562864221149781

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