Targeting SARS‐CoV‐2 by synthetic dual‐acting thiol compounds that inhibit Spike/ACE2 interaction and viral protein production

The SARS‐CoV‐2 life cycle is strictly dependent on the environmental redox state that influences both virus entry and replication. A reducing environment impairs the binding of the spike protein (S) to the angiotensin‐converting enzyme 2 receptor (ACE2), while a highly oxidizing environment is thoug...

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Detalles Bibliográficos
Autores principales: Fraternale, Alessandra, De Angelis, Marta, De Santis, Riccardo, Amatore, Donatella, Masini, Sofia, Monittola, Francesca, Menotta, Michele, Biancucci, Federica, Bartoccini, Francesca, Retini, Michele, Fiori, Valentina, Fioravanti, Raoul, Magurano, Fabio, Chiarantini, Laura, Lista, Florigio, Piersanti, Giovanni, Palamara, Anna T., Nencioni, Lucia, Magnani, Mauro, Crinelli, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880737/
https://www.ncbi.nlm.nih.gov/pubmed/36583713
http://dx.doi.org/10.1096/fj.202201157RR

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880737/
https://www.ncbi.nlm.nih.gov/pubmed/36583713
http://dx.doi.org/10.1096/fj.202201157RR

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