Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion

Aminoacyl-tRNA synthetases (AARSs), a family of essential protein synthesis enzymes, are attractive targets for drug development. Although several different types of AARS inhibitors have been identified, AARS covalent inhibitors have not been reported. Here we present five unusual crystal structures...

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Detalles Bibliográficos
Autores principales: Qiao, Hang, Xia, Mingyu, Cheng, Yiyuan, Zhou, Jintong, Zheng, Li, Li, Wei, Wang, Jing, Fang, Pengfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880928/
https://www.ncbi.nlm.nih.gov/pubmed/36707692
http://dx.doi.org/10.1038/s42003-023-04517-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880928/
https://www.ncbi.nlm.nih.gov/pubmed/36707692
http://dx.doi.org/10.1038/s42003-023-04517-7

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