Cargando…
Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion
Aminoacyl-tRNA synthetases (AARSs), a family of essential protein synthesis enzymes, are attractive targets for drug development. Although several different types of AARS inhibitors have been identified, AARS covalent inhibitors have not been reported. Here we present five unusual crystal structures...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9880928/ https://www.ncbi.nlm.nih.gov/pubmed/36707692 http://dx.doi.org/10.1038/s42003-023-04517-7 |