Neurosteroid Modulation of GABA(A) Receptor Function by Independent Action at Multiple Specific Binding Sites

Neurosteroids are endogenous modulators of GABA(A) receptors that mediate anxiety, pain, mood and arousal. The 3-hydroxyl epimers, allopregnanolone (3α-OH) and epi-allopregnanolone (3β-OH) are both prevalent in the mammalian brain and produce opposite effects on GABA(A) receptor function, acting as...

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Detalles Bibliográficos
Autores principales: Wang, Lei, Covey, Douglas F., Akk, Gustav, Evers, Alex S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881108/
https://www.ncbi.nlm.nih.gov/pubmed/34856904
http://dx.doi.org/10.2174/1570159X19666211202150041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881108/
https://www.ncbi.nlm.nih.gov/pubmed/34856904
http://dx.doi.org/10.2174/1570159X19666211202150041

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