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Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5′-monophosphate as the biological substrate

Eukaryotic life benefits from—and ofttimes critically relies upon—the de novo biosynthesis and supply of vitamins and micronutrients from bacteria. The micronutrient queuosine (Q), derived from diet and/or the gut microbiome, is used as a source of the nucleobase queuine, which once incorporated int...

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Detalles Bibliográficos
Autores principales: Hung, Shr-Hau, Elliott, Gregory I, Ramkumar, Thakku R, Burtnyak, Lyubomyr, McGrenaghan, Callum J, Alkuzweny, Sana, Quaiyum, Samia, Iwata-Reuyl, Dirk, Pan, Xiaobei, Green, Brian D, Kelly, Vincent P, de Crécy-Lagard, Valérie, Swairjo, Manal A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881137/
https://www.ncbi.nlm.nih.gov/pubmed/36610787
http://dx.doi.org/10.1093/nar/gkac1231