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LazySampling and LinearSampling: fast stochastic sampling of RNA secondary structure with applications to SARS-CoV-2

Many RNAs fold into multiple structures at equilibrium, and there is a need to sample these structures according to their probabilities in the ensemble. The conventional sampling algorithm suffers from two limitations: (i) the sampling phase is slow due to many repeated calculations; and (ii) the en...

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Detalles Bibliográficos
Autores principales: Zhang, He, Li, Sizhen, Zhang, Liang, Mathews, David H, Huang, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881153/
https://www.ncbi.nlm.nih.gov/pubmed/36401871
http://dx.doi.org/10.1093/nar/gkac1029