Cis-mediated interactions of the SARS-CoV-2 frameshift RNA alter its conformations and affect function

The RNA genome of SARS-CoV-2 contains a frameshift stimulatory element (FSE) that allows access to an alternative reading frame through −1 programmed ribosomal frameshifting (PRF). −1PRF in the 1a/1b gene is essential for efficient viral replication and transcription of the viral genome. −1PRF effic...

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Detalles Bibliográficos
Autores principales: Pekarek, Lukas, Zimmer, Matthias M, Gribling-Burrer, Anne-Sophie, Buck, Stefan, Smyth, Redmond, Caliskan, Neva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881162/
https://www.ncbi.nlm.nih.gov/pubmed/36537211
http://dx.doi.org/10.1093/nar/gkac1184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881162/
https://www.ncbi.nlm.nih.gov/pubmed/36537211
http://dx.doi.org/10.1093/nar/gkac1184

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