Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases

[Image: see text] Iminosugar scaffolds are highly sought-after pharmaceutical targets, but their chemical synthesis is lengthy and can suffer from poor scalability and purification. Here we report protecting-group-free chemoenzymatic and biocatalytic cascades to synthesize iminosugars from sugar-der...

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Detalles Bibliográficos
Autores principales: Swanson, Christopher R. B., Ford, Grayson J., Mattey, Ashley P., Gourbeyre, Léa, Flitsch, Sabine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881201/
https://www.ncbi.nlm.nih.gov/pubmed/36712485
http://dx.doi.org/10.1021/acscentsci.2c01169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881201/
https://www.ncbi.nlm.nih.gov/pubmed/36712485
http://dx.doi.org/10.1021/acscentsci.2c01169

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