Cargando…

Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion

BACKGROUND: Circular RNAs (circRNAs) can act as microRNA (miRNA) sponges, thus regulating gene expression. The role of circRNAs in the process of oxygen-glucose deprivation/reoxygenation (OGD/R) is unclear. Here, we explored the mechanism underlying Circ VRK1 in human brain microvascular endothelial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Lei, Du, Hong, Zhang, Xuejing, Gao, Bulang, Zhang, Dongliang, Qiao, Zongrong, Su, Xianhui, Bao, Tong, Han, Siqin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881374/ https://www.ncbi.nlm.nih.gov/pubmed/36707796 http://dx.doi.org/10.1186/s12868-023-00774-8

Ejemplares similares

Complications and long-term in-stent restenosis of endovascular treatment of severe symptomatic intracranial atherosclerotic stenosis and relevant risk factors
por: Yang, Lei, et al.
Publicado: (2023)

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma
por: Shields, Julie A., et al.
Publicado: (2022)

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
por: Vázquez-Cedeira, Marta, et al.
Publicado: (2011)

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer
por: Lee, Namgyu, et al.
Publicado: (2017)

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system
por: So, Jonathan, et al.
Publicado: (2022)

Proteomics Identification of Nuclear Ran GTPase as an Inhibitor of Human VRK1 and VRK2 (Vaccinia-related Kinase) Activities
por: Sanz-García, Marta, et al.
Publicado: (2008)

CircRNA mmu_circ_0000021 regulates microvascular function via the miR-143-3p/NPY axis and intracellular calcium following ischemia/reperfusion injury
por: Xiong, Jingjie, et al.
Publicado: (2022)

Autonomous pick-and-place using the dVRK
por: D’Ettorre, Claudia, et al.
Publicado: (2021)

VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1
por: Monte-Serrano, Eva, et al.
Publicado: (2023)

The C/H3 Domain of p300 Is Required to Protect VRK1 and VRK2 from their Downregulation Induced by p53
por: Valbuena, Alberto, et al.
Publicado: (2008)

Shuxuetong injection protects cerebral microvascular endothelial cells against oxygen-glucose deprivation reperfusion
por: Sun, Zuo-Yan, et al.
Publicado: (2019)

Circular RNA VRK1 facilitates pre‐eclampsia progression via sponging miR‐221‐3P to regulate PTEN/Akt
por: Li, Ziwei, et al.
Publicado: (2021)

CircCDR1as Suppresses Bone Microvascular Endothelial Cell Activity and Angiogenesis Through Targeting miR‐135b/ FIH‐1 Axis
por: Mao, Zheng, et al.
Publicado: (2021)

Functional characterization of lysosomal interaction of Akt with VRK2
por: Hirata, Noriyuki, et al.
Publicado: (2018)

Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways
por: Vinograd-Byk, Hadar, et al.
Publicado: (2018)

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes
por: Martín-Doncel, Elena, et al.
Publicado: (2019)

The Role of PTEN in Tumor Angiogenesis
por: Rodriguez, Stéphane, et al.
Publicado: (2012)

LOXL1-AS1 Aggravates Myocardial Ischemia/Reperfusion Injury Through the miR-761/PTEN Axis
por: He, Wenhua, et al.
Publicado: (2023)

Downregulation of circ_0000673 Promotes Cell Proliferation and Migration in Endometriosis via the Mir-616-3p/PTEN Axis
por: Yang, Yongwen, et al.
Publicado: (2021)

17β-Estradiol Promotes Angiogenesis of Rat Cardiac Microvascular Endothelial Cells In Vitro
por: Liu, HaiTao, et al.
Publicado: (2018)

Interleukin-35 Is Involved in Angiogenesis/Bone Remodeling Coupling Through T Helper 17/Interleukin-17 Axis
por: Zhang, Hui, et al.
Publicado: (2021)

CircSTAM inhibits migration and invasion of trophoblast cells by regulating miR-148a-5p/PTEN axis
por: Chen, Lingfeng, et al.
Publicado: (2022)

VRK-1 extends life span by activation of AMPK via phosphorylation
por: Park, Sangsoon, et al.
Publicado: (2020)

Data on the identification of VRK2 as a mediator of PD-1 function
por: Peled, Michael, et al.
Publicado: (2021)

circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway
por: Li, Chen, et al.
Publicado: (2021)

A novel VRK1 mutation associated with recessive distal hereditary motor neuropathy
por: Feng, Shu‐Yan, et al.
Publicado: (2018)

Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage
por: Du, Ning, et al.
Publicado: (2023)

Dexmedetomidine attenuates oxygen-glucose deprivation/ reperfusion-induced inflammation through the miR-17-5p/ TLR4/ NF-κB axis
por: Suo, Liangyuan, et al.
Publicado: (2022)

Circ_0007444 Inhibits the Progression of Ovarian Cancer via Mediating the miR-570-3p/PTEN Axis
por: Wu, Xinyu, et al.
Publicado: (2021)

miR-17-5p attenuates kidney ischemia-reperfusion injury by inhibiting the PTEN and BIM pathways
por: Ma, Ming, et al.
Publicado: (2021)

CircTLK1 alleviates oxygen-glucose deprivation/reperfusion induced apoptosis in HK-2 cells through miR-136-5p/Bcl2 signal axis
por: Kuang, Liting, et al.
Publicado: (2023)

Effects of VRK2 (rs2312147) on White Matter Connectivity in Patients with Schizophrenia
por: Sohn, Hoyoung, et al.
Publicado: (2014)

Novel motor phenotypes in patients with VRK1 mutations without pontocerebellar hypoplasia
por: Stoll, Marion, et al.
Publicado: (2016)

Adult-Onset Spinal Muscular Atrophy due to Mutations in the VRK1 Gene
por: Sung, Angela, et al.
Publicado: (2021)

VRK1 Depletion Facilitates the Synthetic Lethality of Temozolomide and Olaparib in Glioblastoma Cells
por: Navarro-Carrasco, Elena, et al.
Publicado: (2021)

circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p/PTEN Axis and Participating in the Immune Response
por: Zhang, Yinglang, et al.
Publicado: (2023)

Benzoylaconine improves mitochondrial function in oxygen-glucose deprivation and reperfusion-induced cardiomyocyte injury by activation of the AMPK/PGC-1 axis
por: Chen, Leijie, et al.
Publicado: (2022)

Circ_0001897 regulates high glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-29c-3p/transforming growth factor beta 2 axis
por: Gong, Yudan, et al.
Publicado: (2022)

Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells
por: Yan, Ningning, et al.
Publicado: (2017)

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway
por: Valbuena, Alberto, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_27p4f0tbe5tqdvuampi6mv86fc