Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems

Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed. They form DNA interstrand crosslinks (ICLs), which cause a blockage of DNA strand separation, inhibiting essential proces...

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Detalles Bibliográficos
Autores principales: Krassnig, Sarah Ceylan, Mäser, Marina, Probst, Nicola Anna, Werner, Jens, Schlett, Charlotte, Schumann, Nina, von Scheven, Gudrun, Mangerich, Aswin, Bürkle, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881385/
https://www.ncbi.nlm.nih.gov/pubmed/36714466
http://dx.doi.org/10.1016/j.toxrep.2023.01.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881385/
https://www.ncbi.nlm.nih.gov/pubmed/36714466
http://dx.doi.org/10.1016/j.toxrep.2023.01.010

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