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Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems
Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed. They form DNA interstrand crosslinks (ICLs), which cause a blockage of DNA strand separation, inhibiting essential proces...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881385/ https://www.ncbi.nlm.nih.gov/pubmed/36714466 http://dx.doi.org/10.1016/j.toxrep.2023.01.010 |