Cargando…
Comparative analysis of chlorambucil-induced DNA lesion formation and repair in a spectrum of different human cell systems
Chlorambucil (CLB) belongs to the class of nitrogen mustards (NMs), which are highly reactive bifunctional alkylating agents and were the first chemotherapeutic agents developed. They form DNA interstrand crosslinks (ICLs), which cause a blockage of DNA strand separation, inhibiting essential proces...
Autores principales: | Krassnig, Sarah Ceylan, Mäser, Marina, Probst, Nicola Anna, Werner, Jens, Schlett, Charlotte, Schumann, Nina, von Scheven, Gudrun, Mangerich, Aswin, Bürkle, Alexander |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881385/ https://www.ncbi.nlm.nih.gov/pubmed/36714466 http://dx.doi.org/10.1016/j.toxrep.2023.01.010 |
Ejemplares similares
-
Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets Inflammation
por: Mangerich, Aswin, et al.
Publicado: (2012) -
Fueling genome maintenance: On the versatile roles of NAD(+) in preserving DNA integrity
por: Ruszkiewicz, Joanna A., et al.
Publicado: (2022) -
Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
por: Krüger, Annika, et al.
Publicado: (2020) -
Chlorambucil-Induced Acute Interstitial Pneumonitis
por: Shafqat, Hammad, et al.
Publicado: (2014) -
Potent Chlorambucil-Platinum(IV) Prodrugs
por: Aputen, Angelico D., et al.
Publicado: (2022)