Reconfigurable asymmetric protein assemblies through implicit negative design

Asymmetric multi-protein complexes that undergo subunit exchange play central roles in biology, but present a challenge for design since the components must contain interfaces enabling reversible association but be stable and well behaved in isolation. We use implicit negative design to generate bet...

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Detalles Bibliográficos
Autores principales: Sahtoe, Danny D., Praetorius, Florian, Courbet, Alexis, Hsia, Yang, Wicky, Basile I.M., Edman, Natasha I., Miller, Lauren M., Timmermans, Bart J. R., Decarreau, Justin, Morris, Hana M., Kang, Alex, Bera, Asim K., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881579/
https://www.ncbi.nlm.nih.gov/pubmed/35050655
http://dx.doi.org/10.1126/science.abj7662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881579/
https://www.ncbi.nlm.nih.gov/pubmed/35050655
http://dx.doi.org/10.1126/science.abj7662

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