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Reconfigurable asymmetric protein assemblies through implicit negative design
Asymmetric multi-protein complexes that undergo subunit exchange play central roles in biology, but present a challenge for design since the components must contain interfaces enabling reversible association but be stable and well behaved in isolation. We use implicit negative design to generate bet...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881579/ https://www.ncbi.nlm.nih.gov/pubmed/35050655 http://dx.doi.org/10.1126/science.abj7662 |