Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies

Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and provoke antitumor potential. Herein, molecular docking studies were used to investigate the binding interactions of 138 antibiotics against t...

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Detalles Bibliográficos
Autores principales: Farouk, Faten, Elmaaty, Ayman Abo, Elkamhawy, Ahmed, Tawfik, Haytham O., Alnajjar, Radwan, Abourehab, Mohammed A. S., Saleh, Mohamed A., Eldehna, Wagdy M., Al‐Karmalawy, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881673/
https://www.ncbi.nlm.nih.gov/pubmed/36701269
http://dx.doi.org/10.1080/14756366.2023.2171029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881673/
https://www.ncbi.nlm.nih.gov/pubmed/36701269
http://dx.doi.org/10.1080/14756366.2023.2171029

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