Cargando…

Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies

Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and provoke antitumor potential. Herein, molecular docking studies were used to investigate the binding interactions of 138 antibiotics against t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farouk, Faten, Elmaaty, Ayman Abo, Elkamhawy, Ahmed, Tawfik, Haytham O., Alnajjar, Radwan, Abourehab, Mohammed A. S., Saleh, Mohamed A., Eldehna, Wagdy M., Al‐Karmalawy, Ahmed A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881673/ https://www.ncbi.nlm.nih.gov/pubmed/36701269 http://dx.doi.org/10.1080/14756366.2023.2171029

Ejemplares similares

Anticoagulants as Potential SARS-CoV-2 M(pro) Inhibitors for COVID-19 Patients: In Vitro, Molecular Docking, Molecular Dynamics, DFT, and SAR Studies
por: Abo Elmaaty, Ayman, et al.
Publicado: (2022)

Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity
por: Mourad, Mai A. E., et al.
Publicado: (2023)

Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main protease
por: Alnajjar, Radwan, et al.
Publicado: (2020)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR(WT) and EGFR(T790M) inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Revisiting activity of some glucocorticoids as a potential inhibitor of SARS-CoV-2 main protease: theoretical study
por: Elmaaty, Ayman Abo, et al.
Publicado: (2021)

Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators
por: El-Behairy, Mohammed Farrag, et al.
Publicado: (2023)

Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Revisiting Activity of Some Nocodazole Analogues as a Potential Anticancer Drugs Using Molecular Docking and DFT Calculations
por: Khattab, Muhammad, et al.
Publicado: (2021)

Investigating the Potential Anti-SARS-CoV-2 and Anti-MERS-CoV Activities of Yellow Necklacepod among Three Selected Medicinal Plants: Extraction, Isolation, Identification, In Vitro, Modes of Action, and Molecular Docking Studies
por: Abd-Alla, Howaida I., et al.
Publicado: (2022)

Anticholinesterase Activity of Budmunchiamine Alkaloids Revealed by Comparative Chemical Profiling of Two Albizia spp., Molecular Docking and Dynamic Studies
por: Hussein, Mai E., et al.
Publicado: (2022)

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease
por: Elagawany, Mohamed, et al.
Publicado: (2022)

Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives
por: Elkamhawy, Ahmed, et al.
Publicado: (2022)

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies
por: Al-Karmalawy, Ahmed A., et al.
Publicado: (2023)

Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies
por: Khalifa, Mohamed M., et al.
Publicado: (2021)

Voreloxin Is an Anticancer Quinolone Derivative that Intercalates DNA and Poisons Topoisomerase II
por: Hawtin, Rachael E., et al.
Publicado: (2010)

Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 inhibitors
por: Belal, Amany, et al.
Publicado: (2022)

Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies
por: Zaki, Ahmed A., et al.
Publicado: (2021)

Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4,5-dihydropyrazoles as anticancer agents with potential EGFR inhibitory activity
por: Eldehna, Wagdy M., et al.
Publicado: (2022)

Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies
por: El-Seadawy, Hosam M., et al.
Publicado: (2022)

Metabolomic profile, anti-trypanosomal potential and molecular docking studies of Thunbergia grandifolia
por: El-Nashar, Heba A. S., et al.
Publicado: (2023)

Synthesis, Biological Evaluation and Molecular Docking of Certain Sulfones as Potential Nonazole Antifungal Agents
por: Fares, Mohamed, et al.
Publicado: (2016)

A Systematic Review of the Global Intervention for SARS-CoV-2 Combating: From Drugs Repurposing to Molnupiravir Approval
por: Ashour, Nada A, et al.
Publicado: (2022)

Novel saccharin analogs as promising antibacterial and anticancer agents: synthesis, DFT, POM analysis, molecular docking, molecular dynamic simulations, and cell-based assay
por: Abdellattif, Magda H., et al.
Publicado: (2022)

Molecular docking analysis of α-Topoisomerase II with δ-Carboline derivatives as potential anticancer agents
por: Ayyamperumal, Selvaraj, et al.
Publicado: (2021)

In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity
por: Elmaaty, Ayman Abo, et al.
Publicado: (2021)

In Silico Docking, Resistance Modulation and Biofilm Gene Expression in Multidrug-Resistant Acinetobacter baumannii via Cinnamic and Gallic Acids
por: Abdelaziz, Neveen A., et al.
Publicado: (2022)

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization
por: Abo Elmaaty, Ayman, et al.
Publicado: (2021)

Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines
por: Son, Seohyun, et al.
Publicado: (2023)

Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations
por: Nada, Hossam, et al.
Publicado: (2022)

GC/MS Analysis of Essential Oil and Enzyme Inhibitory Activities of Syzygium cumini (Pamposia) Grown in Egypt: Chemical Characterization and Molecular Docking Studies
por: El-Nashar, Heba A. S., et al.
Publicado: (2021)

Identification of Novel Cyanopyridones and Pyrido[2,3-d]pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Identification of a New Potential SARS-COV-2 RNA-Dependent RNA Polymerase Inhibitor via Combining Fragment-Based Drug Design, Docking, Molecular Dynamics, and MM-PBSA Calculations
por: El Hassab, Mahmoud A., et al.
Publicado: (2020)

Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from Jasminum humile
por: Mansour, Khaled Ahmed, et al.
Publicado: (2022)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

DNA topoisomerases as molecular targets for anticancer drugs
por: Buzun, Kamila, et al.
Publicado: (2020)

Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

β-Blockers bearing hydroxyethylamine and hydroxyethylene as potential SARS-CoV-2 Mpro inhibitors: rational based design, in silico, in vitro, and SAR studies for lead optimization
por: Hamed, Mohammed I. A., et al.
Publicado: (2021)

Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies
por: Aly, Shaza H., et al.
Publicado: (2023)

Pyrrolizine/Indolizine-NSAID Hybrids: Design, Synthesis, Biological Evaluation, and Molecular Docking Studies
por: Abourehab, Mohammed A. S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_p6d33r7bttua3eg2hj6t9mmuqu