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Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors

The Ca(2+) and ADP ribose (ADPR)-activated cation channel TRPM2 is the closest homolog of the cold sensor TRPM8 but serves as a deep-brain warmth sensor. To unravel the molecular mechanism of heat sensing by the TRPM2 protein, we study here temperature dependence of TRPM2 currents in cell-free membr...

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Detalles Bibliográficos
Autores principales: Bartók, Ádám, Csanády, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881722/
https://www.ncbi.nlm.nih.gov/pubmed/36409885
http://dx.doi.org/10.1073/pnas.2212378119