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Dual amplification strategy turns TRPM2 channels into supersensitive central heat detectors
The Ca(2+) and ADP ribose (ADPR)-activated cation channel TRPM2 is the closest homolog of the cold sensor TRPM8 but serves as a deep-brain warmth sensor. To unravel the molecular mechanism of heat sensing by the TRPM2 protein, we study here temperature dependence of TRPM2 currents in cell-free membr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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National Academy of Sciences
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881722/ https://www.ncbi.nlm.nih.gov/pubmed/36409885 http://dx.doi.org/10.1073/pnas.2212378119 |