Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster

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Tandem gene duplicates are important parts of eukaryotic genome structure, yet the phenotypic effects of new tandem duplications are not well-understood, in part owing to a lack of techniques to build and modify them. We introduce a method, Recombinase-Mediated Tandem Duplication (RMTD), to engineer...

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Detalles Bibliográficos
Autores principales: Loehlin, David W., McClain, Georgia L., Xu, Manting, Kedia, Ria, Root, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881931/
https://www.ncbi.nlm.nih.gov/pubmed/36711585
http://dx.doi.org/10.1101/2023.01.08.523181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881931/
https://www.ncbi.nlm.nih.gov/pubmed/36711585
http://dx.doi.org/10.1101/2023.01.08.523181

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