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Demonstration of in vivo engineered tandem duplications of varying sizes using CRISPR and recombinases in Drosophila melanogaster

Tandem gene duplicates are important parts of eukaryotic genome structure, yet the phenotypic effects of new tandem duplications are not well-understood, in part owing to a lack of techniques to build and modify them. We introduce a method, Recombinase-Mediated Tandem Duplication (RMTD), to engineer...

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Detalles Bibliográficos
Autores principales: Loehlin, David W., McClain, Georgia L., Xu, Manting, Kedia, Ria, Root, Elise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881931/
https://www.ncbi.nlm.nih.gov/pubmed/36711585
http://dx.doi.org/10.1101/2023.01.08.523181