Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma

Autophagy dysfunction has been associated with several neurodegenerative diseases including glaucoma, characterized by the degeneration of retinal ganglion cells (RGCs). However, the mechanisms by which autophagy dysfunction promotes RGC damage remain unclear. Here, we hypothesized that perturbation...

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Detalles Bibliográficos
Autores principales: Huang, Kang-Chieh, Gomes, Cátia, Shiga, Yukihiro, Belforte, Nicolas, VanderWall, Kirstin B., Lavekar, Sailee S., Fligor, Clarisse M., Harkin, Jade, Di Polo, Adriana, Meyer, Jason S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881969/
https://www.ncbi.nlm.nih.gov/pubmed/36711831
http://dx.doi.org/10.1101/2023.01.04.522687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881969/
https://www.ncbi.nlm.nih.gov/pubmed/36711831
http://dx.doi.org/10.1101/2023.01.04.522687

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