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Understanding and evaluating ambiguity in single-cell and single-nucleus RNA-sequencing

Recently, a new modification has been proposed by Hjörleifsson and Sullivan et al. to the model used to classify the splicing status of reads (as spliced (mature), unspliced (nascent), or ambiguous) in single-cell and single-nucleus RNA-seq data. Here, we evaluate both the theoretical basis and prac...

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Detalles Bibliográficos
Autores principales: He, Dongze, Soneson, Charlotte, Patro, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9881993/
https://www.ncbi.nlm.nih.gov/pubmed/36711921
http://dx.doi.org/10.1101/2023.01.04.522742