Exploiting allele-specific transcriptional effects of subclonal copy number alterations for genotype-phenotype mapping in cancer cell populations

Somatic copy number alterations drive aberrant gene expression in cancer cells. In tumors with high levels of chromosomal instability, subclonal copy number alterations (CNAs) are a prevalent feature which often result in heterogeneous cancer cell populations with distinct phenotypes(1). However, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Hongyu, Williams, Marc J., Satas, Gryte, Weiner, Adam C., McPherson, Andrew, Shah, Sohrab P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882029/
https://www.ncbi.nlm.nih.gov/pubmed/36711951
http://dx.doi.org/10.1101/2023.01.10.523464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882029/
https://www.ncbi.nlm.nih.gov/pubmed/36711951
http://dx.doi.org/10.1101/2023.01.10.523464

Ejemplares similares