Oncogene-like addiction to aneuploidy in human cancers

Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. U...

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Detalles Bibliográficos
Autores principales: Girish, Vishruth, Lakhani, Asad A., Scaduto, Christine M., Thompson, Sarah L., Brown, Leanne M., Hagenson, Ryan A., Sausville, Erin L., Mendelson, Brianna E., Lukow, Devon A., Yuan, Monet Lou, Kandikuppa, Pranav K., Stevens, Eric C., Lee, Sophia N., Salovska, Barbora, Li, Wenxue, Smith, Joan C., Taylor, Alison M., Martienssen, Robert A., Liu, Yansheng, Sun, Ruping, Sheltzer, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882055/
https://www.ncbi.nlm.nih.gov/pubmed/36711674
http://dx.doi.org/10.1101/2023.01.09.523344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882055/
https://www.ncbi.nlm.nih.gov/pubmed/36711674
http://dx.doi.org/10.1101/2023.01.09.523344

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