Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor

Hsp90 is an essential molecular chaperone responsible for the folding and activation of hundreds of ‘client’ proteins, including the glucocorticoid receptor (GR)(1–3). Previously, we revealed that GR ligand binding activity is inhibited by Hsp70 and restored by Hsp90, aided by co-chaperones(4). We t...

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Detalles Bibliográficos
Autores principales: Noddings, Chari M., Johnson, Jill L., Agard, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882067/
https://www.ncbi.nlm.nih.gov/pubmed/36711821
http://dx.doi.org/10.1101/2023.01.10.523504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882067/
https://www.ncbi.nlm.nih.gov/pubmed/36711821
http://dx.doi.org/10.1101/2023.01.10.523504

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