Apo- and holo- transferrin differentially interact with ferroportin and hephaestin to regulate iron release at the blood-brain barrier

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BACKGROUND: Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood-brain barrier. Apo-Tf indicates an iron deficient environment and stimulates iron release, while holo-Tf indicates an iron sufficient environm...

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Detalles Bibliográficos
Autores principales: Baringer, Stephanie L., Palsa, Kondaiah, Simpson, Ian A., Connor, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882075/
https://www.ncbi.nlm.nih.gov/pubmed/36712094
http://dx.doi.org/10.1101/2023.01.10.522344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882075/
https://www.ncbi.nlm.nih.gov/pubmed/36712094
http://dx.doi.org/10.1101/2023.01.10.522344

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