Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

Skeletal fragility is associated with type 2 diabetes mellitus (T2D), but the underlying mechanism is not well understood. Here, in a mouse model for youth-onset T2D, we show that both trabecular and cortical bone mass are reduced due to diminished osteoblast activity. Stable isotope tracing in vivo...

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Detalles Bibliográficos
Autores principales: Song, Fangfang, Lee, Won Dong, Marmo, Tyler, Ji, Xing, Song, Chao, Liao, Xueyang, Seeley, Rebbeca, Yao, Lutian, Liu, Haoran, Long, Fanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882117/
https://www.ncbi.nlm.nih.gov/pubmed/36711657
http://dx.doi.org/10.1101/2023.01.16.524248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882117/
https://www.ncbi.nlm.nih.gov/pubmed/36711657
http://dx.doi.org/10.1101/2023.01.16.524248

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