Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

Senescence drives organismal aging, yet the deep characterization of senescent cells in vivo remains incomplete. Here, we applied mass cytometry by time-of-flight (CyTOF) using carefully validated antibodies to analyze senescent cells at single-cell resolution. We used multiple criteria to identify...

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Detalles Bibliográficos
Autores principales: Doolittle, Madison L., Saul, Dominik, Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Pavelko, Kevin D., Farr, Joshua N., Monroe, David G., Khosla, Sundeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882155/
https://www.ncbi.nlm.nih.gov/pubmed/36711531
http://dx.doi.org/10.1101/2023.01.12.523760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882155/
https://www.ncbi.nlm.nih.gov/pubmed/36711531
http://dx.doi.org/10.1101/2023.01.12.523760

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