Single nucleus multiome analysis of the prefrontal cortex from C9orf72 ALS/FTD patients illuminates pathways affected during disease progression

Repeat expansions in the C9orf72 gene are the most common genetic cause of amyotrophic lateral sclerosis and familial frontotemporal dementia (ALS/FTD). To identify molecular defects that take place in the dorsolateral frontal cortex of patients with C9orf72 ALS/FTD, we compared healthy controls wit...

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Detalles Bibliográficos
Autores principales: Wang, Hsiao-Lin V., Veire, Austin M., Gendron, Tania F., Gearing, Marla, Glass, Jonathan D., Jin, Peng, Corces, Victor G., McEachin, Zachary T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882184/
https://www.ncbi.nlm.nih.gov/pubmed/36711601
http://dx.doi.org/10.1101/2023.01.12.523820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882184/
https://www.ncbi.nlm.nih.gov/pubmed/36711601
http://dx.doi.org/10.1101/2023.01.12.523820

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