Analysis of the molecular determinants for furin cleavage of the spike protein S1/S2 site in defined strains of the prototype coronavirus murine hepatitis virus (MHV)

We have analyzed the spike protein S1/S2 cleavage site of selected strains of MHV by the cellular protease furin, in order to understand the structural requirements underlying the sequence selectivity of the scissile segment. The probability of cleavage of the various MHV strains was first evaluated...

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Detalles Bibliográficos
Autores principales: Choi, Annette, Kots, Ekaterina D., Singleton, Deanndria T., Weinstein, Harel A., Whittaker, Gary R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882190/
https://www.ncbi.nlm.nih.gov/pubmed/36711446
http://dx.doi.org/10.1101/2023.01.11.523687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882190/
https://www.ncbi.nlm.nih.gov/pubmed/36711446
http://dx.doi.org/10.1101/2023.01.11.523687

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