Cargando…

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

Pharmacological activation of the activating transcription factor 6 (ATF6) arm of the Unfolded Protein Response (UPR) has proven useful for ameliorating proteostasis deficiencies in a variety of etiologically diverse diseases. Previous high-throughput screening efforts identified the small molecule...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kline, Gabriel M., Paxman, Ryan J, Lin, Chung-Yon, Madrazo, Nicole, Grandjean, Julia M., Lee, Kyunga, Nugroho, Karina, Powers, Evan T., Wiseman, R. Luke, Kelly, Jeffery W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882204/ https://www.ncbi.nlm.nih.gov/pubmed/36712115 http://dx.doi.org/10.1101/2023.01.16.524237

Ejemplares similares

Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators
por: Kline, Gabriel M., et al.
Publicado: (2023)

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
por: Paxman, Ryan, et al.
Publicado: (2018)

Pharmacologic IRE1/XBP1s Activation Confers Targeted ER Proteostasis Reprogramming
por: Grandjean, Julia M.D., et al.
Publicado: (2020)

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors
por: Mesgarzadeh, Jaleh S., et al.
Publicado: (2022)

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress
por: Romine, Isabelle C., et al.
Publicado: (2019)

Endoplasmic reticulum proteostasis impairment in aging
por: Martínez, Gabriela, et al.
Publicado: (2017)

Proteostasis in the Endoplasmic Reticulum: Road to Cure
por: Nam, Su Min, et al.
Publicado: (2019)

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
por: Blackwood, Erik A., et al.
Publicado: (2019)

Endoplasmic Reticulum Ca(2+) Increases Enhance Mutant Glucocerebrosidase Proteostasis
por: Ong, Derrick Sek Tong, et al.
Publicado: (2010)

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress
por: Lebeau, Justine, et al.
Publicado: (2018)

Remodeling the endoplasmic reticulum proteostasis network restores proteostasis of pathogenic GABA(A) receptors
por: Fu, Yan-Lin, et al.
Publicado: (2018)

Mastering organismal aging through the endoplasmic reticulum proteostasis network
por: Taylor, Rebecca C., et al.
Publicado: (2020)

The Critical Roles of Proteostasis and Endoplasmic Reticulum Stress in Atrial Fibrillation
por: Sirish, Padmini, et al.
Publicado: (2022)

Editorial: Restoring endoplasmic reticulum proteostasis to treat neurological disorders
por: Medinas, Danilo B., et al.
Publicado: (2023)

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
por: Preissler, Steffen, et al.
Publicado: (2020)

The endoplasmic reticulum membrane complex promotes proteostasis of GABA(A) receptors
por: Whittsette, Angela L., et al.
Publicado: (2022)

Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland
por: Zhang, Xiaohan, et al.
Publicado: (2023)

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
por: Plate, Lars, et al.
Publicado: (2016)

Correction: Gene therapy in Parkinson's disease: targeting the endoplasmic reticulum proteostasis network
Publicado: (2015)

CCPG1, a cargo receptor required for reticulophagy and endoplasmic reticulum proteostasis
por: Smith, Matthew D., et al.
Publicado: (2018)

Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis
por: Matai, Latika, et al.
Publicado: (2019)

A transgenic mouse line for assaying tissue-specific changes in endoplasmic reticulum proteostasis
por: Svarcbahs, Reinis, et al.
Publicado: (2023)

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABA(A) receptors
por: Wang, Meng, et al.
Publicado: (2022)

Metabolically Activated Proteostasis Regulators Protect against Glutamate Toxicity by Activating NRF2
por: Rosarda, Jessica D., et al.
Publicado: (2021)

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation
por: Maurel, Marion, et al.
Publicado: (2019)

Proteostasis Regulation in the Endoplasmic Reticulum: An Emerging Theme in the Molecular Pathology and Therapeutic Management of Familial Hypercholesterolemia
por: Oommen, Deepu, et al.
Publicado: (2020)

The endoplasmic reticulum proteostasis network profoundly shapes the protein sequence space accessible to HIV envelope
por: Yoon, Jimin, et al.
Publicado: (2022)

Stress-responsive regulation of extracellular proteostasis
por: Mesgarzadeh, Jaleh S., et al.
Publicado: (2022)

Uncoupling Proteostasis and Development in Vitro with a Small Molecule Inhibitor of the Pancreatic Endoplasmic Reticulum Kinase, PERK
por: Harding, Heather P., et al.
Publicado: (2012)

Neuroinflammation alters cellular proteostasis by producing endoplasmic reticulum stress, autophagy activation and disrupting ERAD activation
por: Pintado, Cristina, et al.
Publicado: (2017)

Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
por: Kim, In Young, et al.
Publicado: (2017)

Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation
por: Espinoza, Mateo F., et al.
Publicado: (2022)

Endoplasmic Reticulum Redox State Is Not Perturbed by Pharmacological or Pathological Endoplasmic Reticulum Stress in Live Pancreatic β-Cells
por: Schuiki, Irmgard, et al.
Publicado: (2012)

Pharmacological Modulators of Endoplasmic Reticulum Stress in Metabolic Diseases
por: Jung, Tae Woo, et al.
Publicado: (2016)

Curcumin Improves Palmitate-Induced Insulin Resistance in Human Umbilical Vein Endothelial Cells by Maintaining Proteostasis in Endoplasmic Reticulum
por: Ye, Mao, et al.
Publicado: (2017)

Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections
por: Almasy, Katherine M., et al.
Publicado: (2021)

Retraction: Curcumin improves palmitate-induced insulin resistance in human umbilical vein endothelial cells by maintaining proteostasis in endoplasmic reticulum
por: Frontiers Editorial Office
Publicado: (2023)

Modulating protein quality control
por: Plate, Lars, et al.
Publicado: (2016)

Reconstitution of the tubular endoplasmic reticulum network with purified components
por: Powers, Robert E., et al.
Publicado: (2017)

THE ENDOPLASMIC RETICULUM
por: Palade, George E.
Publicado: (1956)

Cannot write session to /tmp/vufind_sessions/sess_q9bu78gkccmrlib77nm064s82b