Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain

Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed whole-genome sequencing of 71 oligodendrocytes and 51 neurons from neurotypical individuals (0.4 t...

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Detalles Bibliográficos
Autores principales: Ganz, Javier, Luquette, Lovelace J., Bizzotto, Sara, Bohrson, Craig L., Jin, Hu, Miller, Michael B., Zhou, Zinan, Galor, Alon, Park, Peter J., Walsh, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882228/
https://www.ncbi.nlm.nih.gov/pubmed/36711756
http://dx.doi.org/10.1101/2023.01.14.523958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882228/
https://www.ncbi.nlm.nih.gov/pubmed/36711756
http://dx.doi.org/10.1101/2023.01.14.523958

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