Reciprocal inhibition of PIN1 and APC/C(CDH1) controls timely G1/S transition and creates therapeutic vulnerability

Cyclin-dependent kinases (CDKs) mediated phosphorylation inactivates the anaphase-promoting complex (APC/C(CDH1)), an E3 ubiquitin ligase that contains the co-activator CDH1, to promote G1/S transition. PIN1 is a phosphorylation-directed proline isomerase and a master cancer signaling regulator. How...

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Detalles Bibliográficos
Autores principales: Ke, Shizhong, Dang, Fabin, Wang, Lin, Chen, Jia-Yun, Naik, Mandar T., Thavamani, Abhishek, Liu, Yansheng, Li, Wenxue, Kim, Nami, Naik, Nandita M., Sui, Huaxiu, Tang, Wei, Qiu, Chenxi, Koikawa, Kazuhiro, Batalini, Felipe, Wang, Xiaodong, Clohessy, John G., Heng, Yujing Jan, Lahav, Galit, Gray, Nathanael S., Zho, Xiao Zhen, Wei, Wenyi, Wulf, Gerburg M., Lu, Kun Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882653/
https://www.ncbi.nlm.nih.gov/pubmed/36711754
http://dx.doi.org/10.21203/rs.3.rs-2447544/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9882653/
https://www.ncbi.nlm.nih.gov/pubmed/36711754
http://dx.doi.org/10.21203/rs.3.rs-2447544/v1

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